Comparison of the Therapeutic Effects of Rectal Diclofenac Sodium and Intramuscular Pethidine Injection in the Treatment of Acute Renal Colic: A Randomized Clinical Trail

Hosseini, Mohammad Mehdi and Yousef, Alireza and Ghahramani, Leila and Rastegari, Mohsen and Ebrahimi, Abdoul-Rasoul (2015) Comparison of the Therapeutic Effects of Rectal Diclofenac Sodium and Intramuscular Pethidine Injection in the Treatment of Acute Renal Colic: A Randomized Clinical Trail. Journal of Clinical Trials.

[img]
Preview
 Text
Comparison of the Therapeutic.pdf
Download (31kB) | Preview

Abstract

of this study was to compare the safety and efficacy of rectal diclofenac sodium (RDS) and intramuscular pethidine (IMP) injection in acute renal colic. Materials and Methods: In an interventional prospective double-blind randomized clinical trial, 541 patients who had referred to our center because of acute renal colic were divided into two groups: (1) RDS with 266 participants and (2) IMP with 275 participants. Pain relief was measured by asking the participants at 10, 20 and 30 minutes after taking each drug. Results: In RDS group, analgesic effects of RDS were apparent in 121 participants (45.5%) after 10 min, in 191 participants (71.9%) after 20 min and in 233 participants (87.5%) after 30 min. 33 participants (12.5%) had no response to RDS. In IMP group, analgesic effects of IMP were apparent in 123 participants (44.7%) after 10 min, in 191 participants (69.5%) after 20 min and in 254 participants (92.3%) after 30 min. 21 participants (7.7%) had no response to IMP. Statistical analysis revealed that there was no significant difference between the two studied drugs in relieving renal colic pain (P=0.06). Conclusion: Although there was no significant difference in analgesic effect between the two drugs, using diclofenac sodium in suppository form is highly recommended for renal colic patients because of availability, being less expensive, safety, and its self-administration. Keywords Renal colic; Diclofenac sodium; Pethidine; Analgesia

Item Type: Article
Subjects: WB Practice Of Medicine
Divisions: School of Medicine
Depositing User: mrs Maryam azmoode
Date Deposited: 22 May 2018 05:50
Last Modified: 22 May 2018 05:50
URI: http://eprints.jums.ac.ir/id/eprint/207

Actions (login required)

View Item View Item
jums is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.